Early striatal amyloid deposition distinguishes Down syndrome and autosomal dominant Alzheimer's disease from late-onset amyloid deposition
نویسندگان
چکیده
منابع مشابه
Striatal beta-amyloid deposition in Parkinson disease with dementia.
Dementia is common in Parkinson disease (PD), although its anatomic and pathologic substrates remain undefined. Recently, striatal abnormalities in Lewy body diseases have been described, but their clinical relevance is not clear. Thirty PD cases from the United Kingdom Parkinson's Disease Society Tissue Bank were grouped as demented (PDD; n = 16) and nondemented (PD; n = 14) based on a review ...
متن کاملAmyloid deposition in Alzheimer's disease.
Alzheimer's disease (AD), a progressive neurodegenerative disorder, accounts for approximately 60 percent of all victims of dementia and affects greater than 10 percent of the population over 65 years old. Although the cause is unknown, there is evidence that beta-amyloid plays an important role in its pathogenesis. The deposition of this type of amyloid in the brain and its implications in AD ...
متن کاملEarly Postmenopausal Transdermal 17β-Estradiol Therapy and Amyloid-β Deposition
BACKGROUND It remains controversial whether hormone therapy in recently postmenopausal women modifies the risk of Alzheimer's disease (AD). OBJECTIVE To investigate the effects of hormone therapy on amyloid-β deposition in recently postmenopausal women. METHODS Participants within 5-36 months past menopause in the Kronos Early Estrogen Prevention Study, a randomized, double blinded placebo-...
متن کاملBrain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline
Individuals with Down syndrome (DS) are more likely to experience earlier onset of multiple facets of physiological aging. This includes brain atrophy, beta amyloid deposition, cognitive decline, and Alzheimer's disease-factors indicative of brain aging. Here, we employed a machine learning approach, using structural neuroimaging data to predict age (i.e., brain-predicted age) in people with DS...
متن کاملLETTER TO THE EDITOR Striatal A-Amyloid Deposition in Parkinson Disease With Dementia
In a recent article, Kalaitzakis et al (1) reported a significantly greater amyloid-A peptide (AA) burden in the striatum of cases of Parkinson disease (PD) with dementia (PDD) than in nondemented PD patients, whereas >synuclein (>SN) and tau deposition were similarly rare in both groups. Because neuritic Braak stages were rather low in both groups, it was concluded that AA deposition in the st...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia
سال: 2018
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2018.01.002